Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos

Summary: To interrogate the alternative fates of pancreas and liver in the earliest stages of human organogenesis, we developed laser capture, RNA amplification, and computational analysis of deep sequencing.Pancreas-enriched gene expression was less conserved between human and mouse than for liver.The dorsal pancreatic bud was enriched for compone

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The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

Abstract Neurodegenerative diseases, a subset of age-driven diseases, have been known to exhibit increased oxidative stress.The resultant increase in reactive oxygen species (ROS) has long been viewed as a detrimental byproduct of many cellular color touch 7/97 processes.Despite this, therapeutic approaches using antioxidants were deemed unsuccessf

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